@"Kiwi Angel" From a 2016 US study:
"Previous large adjuvant endocrine trials have reported no significant decrease in overall health-related quality of life (HRQOL) during adjuvant AI therapy [2–4].
Despite these data, in multiple research and clinical practice settings early discontinuation is common, ranging from 30% to 70% [5].
Although reasons for early discontinuation are multifactorial, data suggest that up to 30% of patients discontinue AI therapy because of adverse symptoms, most commonly arthralgias [6, 7]."