Re dental work - I have just had major dental in prep for hormone therapy. As I am post menopausal and er+ I am to take aromatase inhibitors in my case Letrozole. I am osteoporotic - these drugs thin bones further so need in addition a bone building medication in my case Prolia injections 6 monthly. Prolia and other bone builders risk osteonecrosis of the jaw if major dental work is done hence why I had this work done prior to starting hormone therapy which in my case requires bone building medication as well . I understand women who are premenopausal and er+ are to take tamoxifen which does not have bone implications hence no bone building drugs are necessary and major dental work is not an issue. I have no knowledge about chemo and major dental work however . Major dental work for me meant extractions and implants not minor stuff like fillings.