I didn’t feel any better or worse after each treatment, although I had different side effects from A/C to Taxol. As I kept working and doing normal things, I didn’t give much thought to whether I felt differently or not. Most people will say that keeping busy - whether it’s work, exercise, hobbies or whatever - is worthwhile during chemo. Some actively think about the chemo doing its work, and feel a bit better every time! Anything that lifts the spirits is worth doing. If you concentrate on feeling sad, chances are you may feel worse.