Femara can have a significant impact on bone density, so as others have said, it's usually tested before or soon after starting and monitored in case the impact becomes too significant. I had very good bone density before I started and will end with pretty " average-for-your-age" by the time I finish if I am lucky. However people can break their ankles for all sorts of reasons and if you have only been on Femara a relatively short time, it's unlikely to have caused the break. I did have chemo and my bone density test showed no impact. But again it may depend on what the chemo regimen is. Certainly be worth having your bone density tested now so you know what's what and can look at options for minimising damage.