Hey @SYT I had bone, muscle and nerve pain on Taxol, unfortunately as the weeks went on and infusions went on, I ended up with no reprieve in between at all. I'm drug sensitive, so could only take panadol osteo and Nurofen together, it barely touched the sides. I know some take Lyrica which is for nerve pain, I could never take it, I tried years ago for Fibromyalgia but made me quite ill. Definitely tell your Team ASAP I think Endone only numbs your perception of pain, what about tramadol? Run it by them and let them know Endone does nothing, hopefully they can find something to get you through. Hugs Melinda xo