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fab50's avatar
fab50
Member
2 years ago

Aromatase inhibitor

Hi Everyone
I'm 50 years old, I was diagnosed with stage 1breast cancer in late November last year.
Early December 2022 I had surgery and removed a 18mm & 4.7mm cancerous tumors. The tumors were grade 2 invasive cacinoma DCIS, they were HER2 negative & oestrogen receptor positive, the margins were all clear. There were isolated tumor cells in one lymph node, this node was removed during surgery and the Dr advised it was not a concern.

After the surgery I did a test that confirmed I had the BRACA1 gene.

In March 2023 I had a double mastectomy and breast reconstruction using my own stomach fat. The pathology post-surgery found the right breast all clear, but the left breast had a 3mm triple negative tumour, grade 2 invasive carcinoma NST again margins were all clear. The lymph nodes were all clear.

As a preventative I removed my ovaries and fallopian tubes in early August 2023, pathology came back all clear.

So, my question to everyone out there is since i have removed my ovaries and fallopian tubes plus the double mastectomy I have no breast tissue, I'm very reluctant to take Aromatase inhibitor for 5 years due to the side effects, has anyone done some research on this or experienced the same decision of whether to take Aromatase inhibitor or not, 

Thanks




    
  • Oh @Fab50 you've had a rough ride! Estrogen is still released from fast cells,  I believe,  which is why even after I'm in menopause I'll have to go on an AI.
    Good luck with everything!
  • If an AI is recommended (because your body will still produce some oestrogen), and if it’s the prospect of unpleasant side effects (I am assuming joint pain) that is the main reason for not taking an AI, have you considered trying it and stopping if you get side effects? I have taken an AI for ten years (finished last May, hooray) and I did have some side effects but no joint pain or aches, no
    menopausal symptoms, flushes etc. I experienced some loss in my bone density (but note ten years, not five, and I was nearly 20 years older than you when I started, which makes a difference, there’s a natural loss operating too!). Side effects usually start quite soon, so you can make a decision before anything becomes too difficult. Like chemo, knowing any individual reaction to an AI is tricky. Best of luck whatever you decide. 
  • I wouldn't rule it out entirely, without trying it for yourself. Every one is different in how it affects them. It may be minor for you. Sometimes if you have problems after a reasonable try, there are other similar drugs to switch to. All the best.