Hi @Katiejane777, I've been on zoladex since February and now just started on Arimidex. I'm 43 and was pre menopausal before chemo. Like you I am er positive pr negative and her negative. The first injection I had a bad headache for a week but that's all. Fast forward til now and my joints are stiff and painful, but some of that is from chemo. I had got flushes in the beginning and throughout chemo but they have settled touch wood. I cannot have tamoxifen due to other health complications. The advantage of zoladex is you can also go on aromatase inhibitors. I'm sure you'll be ok but if tamoxifen doesn't work well for you regarding side effects there is other options. By the way, I was petrified at the beginning of all this shit but mostly it's been doable. All the best and I hope this helps a little.