Five months on Tamoxifen and I finally ended up in a foetal position thinking very bad thoughts about not wanting to live. And then feeling so ungrateful because I have been given the opportunity to live. This drug totally messed with my head. After a few ‘breaks’ from it my Oncologist changed me to Arimidex. I was terrified to start because as @"Kiwi Angel" said sometimes it’s better the devil you know. I hated my devil. It’s still early days on Arimidex (now on tablet number 18) but I’m glad to report I’m now on 5 straight days of feeling like my old self. Still awake between 2am and 5am but not struggling with anxiety/teary/mental stuff. Get some warm glows at night but nothing extreme. I’m really hoping this is the right drug for me now. Maybe it’s too soon to tell. Tamoxifen seemed ok at the beginning but over time built up into a nightmare. We are all different and respond differently to meds. It may be worth trying other options if having a break is not working. Hugs to you all xxx