It's interesting..as I asked the medical oncologist a couple of weeks ago if chemotherapy had a cumulative effect and she said no. This is the first cycle I have been as nauseated as I have...nothing seems to alleviate it for very long. I probably shouldn't be complaining as I feel that the first 2 cycles weren't too bad..except for overwhelming fatigue. I only have one more to go and YEH!!!! I'm finished. I then commence radiation. I'm looking forward to the end of treatments. Thanks for your kind thoughts. Chris