I've had two sessions of AC, and I felt much better after the second than the first. With the PICC catheter, I've been doing fine so far. My oncologist is pleased with how I'm coping but mentioned that this is just the beginning and to expect more severe side effects. Honestly, I was hoping for the opposite. It is true, it was his comment when I told him that I plan to work from home when I finish AC. He just told me to take care because of my age ( 64 years old) and when I feel unwell to have break from work. I'm not sure how I'll be with paclitaxel, which I'll start at the beginning of April. The side effects I'm dealing now are cravings and tiredness, which I manage by indulging myself with the foods I love, and when I'm tired, I rest. I still cook and do some light household chores. What I don't enjoy is going out. I also have an elliptical and spend time in my backyard. This is what suits me. My 'outings' are limited to visits to the oncologist, blood tests, PICC catheter management, and chemo sessions. All the best Rona and Katie46 with you Paclitaxel and I hope it will be easier than AC.