Intro + Neoadjuvant or Adjuvant Chemo?

Hi, Just read your story and my heart goes out to you...all of us here have been on the decision making treadmill. Like your wife, my family have been impacted by familial cancer as well and this adds an extra element to consider. Out of the seven girls (sisters) in my family, six of us have been diagnosed with breast cancer over the years. Genetic testing finally revealed the BRACA 2 gene ..but, like your wife, not from our mum. I am also Er+ and PR+ and this has dictated my ongoing treatment course. Due to the BRACA2 involvement, I followed my oncologists advice (not my surgeon) and ended up choosing a mastectomy with sentinel lymph node removal (only 1 was removed) to minimise potential lymphoedema issues later on. I then underwent chemotherapy and am now on medication that cuts down Estrogen and Progesterone production (Aromatase Inhibitors)  I have also had ovaries and fallopian tubes removed as has two other sisters (recommended for BRCA 2  carriers and all of us have now had double mastectomies). The other three sisters chose lumpectomies and radiotherapy but unfortunately, cancer  metatasized later and we have lost them. With respect, I would be seeking an oncologists opinion to add to your knowledge. My surgeon initially recommended a lumpectomy, but changed her advice upon finding out about the BRCA 2 connection.   I will be thinking of you and your wife and hope it all turns out okay..