I wore the same underwire bra post mastectomy that I had worn pre mastectomy, for 12 months. A persistent, very large seroma scuppered my chances to fit a prosthesis. Obviously, the underwire didn’t sit on my scar or anywhere uncomfortable, but with hindsight it may have allowed longer term changes and healing to occur without any different pressure. When I finally got a prosthesis, a professional fitter demonstrated that a bra without underwire could be both comfortable and supportive. I’d have no issue with using underwire again if required.