It does affect those who have been through chemo more yes @Romla as in most cases there is an element of neuropathy, so the AI exacerbates all of it, Im quite active these days...BUT it doesnt change the pain in any way as the damage is irreversible I was told and the AI well its renowned for its symptoms, so the Onc said that's all folks lol. I know there are alot of people who don't want to take anything at all, but I have to say even 2.5yrs post chemo now I have days that I have to have panadol osteo. All the vitamins in the world will not fix the problem...they may help alleviate a little. I believe I am better to where I was purely by the magnesium daily. I used to take Krill oil for years prior to this, but it never did anything. All the research in the world is great but again everybodys DNA is different and not everything works I guess. I'm questioning having taken Vit D now for 2.5 yrs as i have recently developed high BP on top of high cholesterol which that only began after taking AI's. Can't win LOL. Just as well I have a sense of humour because honestly.