Hi Trikki2, I had terrible fatigue during first week of radio and wondered how I was ever going to make it through to the end, and then the 2 weeks after when side effects supposedly peak. Being self employed it was quite stressful. However, I was fortunate to come across a great Chinese Herbal Medicine practitioner. She had the fatigue fixed within a few days. If you're open to alternative therapies it might be suitable for you. Obviously check with your treating docs as they know all the particulars of your health. Some docs seem more flexible to alternatives than others. Good luck xx