My finger nails developed four distinct lines, which corresponded to my first four cycles of chemo. They have also become more curved and I have to be careful to not cut them too short at the sides, as they then grow into the soft skin, much like an ingrown toenail. My toenails first went dark, then a sort of chalky grey / white and the nail of the big toe on the right has come off and regrown twice. It is quite thick and a bit crumbly, but is finally looking as it it will stay. I don't have diabetes, but I do have very bad circulation due to scleroderma, and get terrible Reynaud's in hands and feet, so also have to maintain very strict foot and hand hygiene.