Hi @Adri, I have been on Letrozole for 3 years & have osteopenia. I am having 6 monthly Zometa infusions with 2 so far out of 6. I haven’t had any problems except flu like symptoms for a day after. I will be having a bone density scan later this year to see what effect it has had. Also there is research that it helps protect against bone Mets so was worth it for me.