Interesting question - I have osteopoenic patches, and they shift - some get better, some get a bit worse. I asked my oncologist about Prolia, he didn’t suggest it. I think he’d prescribe it if I wanted (I’d have to pay) but I don’t really fancy it so we have both agreed to just keep monitoring. My bone density was excellent before I started femara, now it’s about average for my age (74). If it doesn’t get any worse, I’ll stay as I am. I know some on the network such as @Romla have found it very beneficial.