Anastrozole
Tell me your experiences with Anastrozole ladies ! Just started taking this a week ago. I will be interested to hear your thoughts.
Forum Discussion
- Dear @Wren20, I just took my daily 1mg Anastrazole tablet with my first cup of coffee. I have been taking Anastrazole since Dec last year. This followed lumpectomy, AC chemo and radiotherapy. I am very lucky; the only side effect for me of the Anastrazole was sore ankles in the first weeks, but this has stopped now. I also take Alendronate for osteoporosis therapy, and a daily calcium tablet to counteract possible bone density loss associated with the Anastrazole. Have you had your bone density tested?
I think you will find some good posts about Anastrazole from the past on this network. You will learn we experience a range of reactions to Anastrazole.
Best wishes from jennyss in Western NSW. - Thanks Jennyss. I am booked in for bone density test. My oncol advised Vit D. Your BC regime sounds very similar to mine. I asked about Anasrozole b/c the very first night that I took the first 1mg tablet, EVERY joint ached and after a week or so of it I have had hip, ankle, knee, finger etc. pain. Unfortunately I also have Rheum Arth, diagnosed 2 years prior to BC, so the joint pain side effects of Anas, may end up being too much for me & an alternative sought. All in all though, I am fine & pleased to be here !
- I'm about to finish radiation and will be starting anastrazole soon. I'll be keeping an eye on this thread and more. Xxx
- I see you all have been on Anastrazole for a couple of years now, how are you all.? I have been taking it for a couple of months and am fine.I never had a bone scan before starting it had it just a few weeks ago and Dr said I am osteopenic so should do Zometa or Prolia treatment. Have done a lot of reading and don’t like any of this so am thinking I won’t go down that road. Are any of you doing this treatment and what are your thoughts. xx
- Interesting question - I have osteopoenic patches, and they shift - some get better, some get a bit worse. I asked my oncologist about Prolia, he didn’t suggest it. I think he’d prescribe it if I wanted (I’d have to pay) but I don’t really fancy it so we have both agreed to just keep monitoring. My bone density was excellent before I started femara, now it’s about average for my age (74). If it doesn’t get any worse, I’ll stay as I am. I know some on the network such as @Romla have found it very beneficial.
- Hi @Wren20, my first time posting here for a while, but I do pop in and out and read how everyone is doing.
I recently finished taking Anastrozole after 12 months if it, folling 4 and a half years of Tamoxifen.
My dr suggeated a bone scan before commencing the Anastrozole and was shocked to find I had severe osteoporosis in my lumbar spine ( he, along with my onc had been sure Tamoxifen would protect against any bone loss). I now have Prolia shots every 6 months to help the osteoporosis.
For me, hand and finger pain was the worst on anastrozole as I already had some osteoarthritis. Im pleased to say though, that my hands have improved a lot since ceasing tablets, except for tendon problems in thumbs. Give it a go, but if you find your joints are giving you too much grief, discuss options with your doctor.
Wishing you the very best, hope you can get some relief and can manage your pain.
Take care, Michele x - Hi @Adri, I have been on Letrozole for 3 years & have osteopenia. I am having 6 monthly Zometa infusions with 2 so far out of 6. I haven’t had any problems except flu like symptoms for a day after. I will be having a bone density scan later this year to see what effect it has had. Also there is research that it helps protect against bone Mets so was worth it for me.
- @Adri I was osteoporotic prior to breast cancer and had had an osteoporotic fracture. As I am Er+ positive hormone therapy was recommended and in my case I was prescribed Letrozole.. Hormone Therapy thins bones so it was recommended I have 6 monthly Prolia injections.
Tbh I was more frightened at the prospect of Prolia than my surgery and radiation based on what I had read.I have had this injection now for 3 years and have had no problems at all.The injection is painless into the upper abdomen by my practice nurse .I was amazed when I asked around how many women I knew also were having the injection 6 monthly - some for osteoporosis and some for osteoarthritis.With Prolia before starting you must have a through dental check prior to commencing as serious dental like extractions or root canals run the risk of osteonecrosis of the jaw. It is important to have regular 6 monthly checkups and I time mine carefully to be between injections as Prolia exits the body entirely after 6 months.Prolia builds bone but is a lifetime treatment as cessation causes rapid bone loss so it’s important to ensure injections are timed carefully to be 6 monthly.
Some years prior to Prolia I had been prescribed bisphosphonate tablets for my osteoporosis. I needed a dental extraction and had great difficulty finding a dentist to help me .Idid in the end get help from the Professor of Dentistry here after performing cross laps testing to ensure bone was turning over. Both Prolia and Bisphosphonate tablets build bone but the tablets stay in your system indefinitely unlike Prolia ie the tablets carry a constant risk of osteonecrosis.Unless you fulfill PBS criteria Prolia injections are very expensive around $280 every 6 months. The PBS criteria is 1) a diagnosis os osteoporosis. AND 2) over 70. OR 2) had an osteoporotic fracture. If you fulfill PBS criteria it’s around $38 every 6 months.
One final point it has been discovered that a Prolia works in conjunction with hormone therapy to further reduce breast cancer recurrence.
Hope this helps . I am doing fine on Prolia as are many other women I know - ask around you might be surprised how many women you know are also. - @Adri @Romla
These journals reviewed the studies that linked Prolia (denosumab) with reducing recurrence risk and the authors do not accept the link for myriad reasons:
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(19)30146-9/fulltext
https://www.ascopost.com/issues/june-25-2019/denosumab-prevents-neither-breast-cancer-relapse-nor-death/
https://www.medpagetoday.com/hematologyoncology/breastcancer/83757
https://www.cancernetwork.com/asco-breast-cancer/adjuvant-denosumab-fails-reduce-recurrences-deaths-early-breast-cancer
It is best to confirm the benefits and risks of the drug with your specialist.
I am posting these links as a reference and cannot engage in discussion about them. - @Adri @Romla
The authors of these articles reviewed the studies that linked Prolia (denosumab) with reducing recurrence risk and do not accept the link:
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(19)30146-9/fulltext
https://www.ascopost.com/issues/june-25-2019/denosumab-prevents-neither-breast-cancer-relapse-nor-death/
https://www.medpagetoday.com/hematologyoncology/breastcancer/83757
https://www.cancernetwork.com/asco-breast-cancer/adjuvant-denosumab-fails-reduce-recurrences-deaths-early-breast-cancer
It is best to confirm the benefits and risks of the drug with your specialist.
I am posting these links as a reference and cannot engage in discussion about them.
