Hi,I found Genox worked best for me but we are all different. My friend had no side effects whatsoever but I had hot flushes,low mood and sleeplessness. I ended up taking a low dose antidepressant called Endep 10mg to counteract it all. It helped. I lasted almost 5yrs on Tamoxifen and then I’d had enough. It’s a balancing act. I would say get your liver function and cholesterol bloods checked before you start,as a base line.Also think about a pelvic ultrasound if you have a uterus.When you start or stop Tamoxifen it’s not uncommon to get pv spotting so don’t be alarmed.Also have an eye test done(at Specsavers?) as a baseline too. Tamoxifen has been around a long time and is very effective so give it your best shot.Discuss all the above precautions with your doc (or not)I can never decide if ignorance is bliss or knowledge is power. Being a retired nurse,I tend towards the latter.