Targin is a slow release drug, Endone or oxycodone is the same, but not slow release. I have other medical conditions, which sometimes have me needing day and night long pain relief at a low to medium level of medication. My experience is that oral medication has peaks and valleys, and that I then get breakthrough pain. I was seen by the professor at the pain clinic of the large Sydney hospital where I'm under the care of a number of specialists. When I get these 'flares' I get put onto Fentanyl patches. They are only the pediatric strength and give a very slow, constant level of pain relief. When the flare passes, I stop using them. I've found that this regime of slow, constant relief works best for me. I hope your team finds a good solution for you too.