Hi @Gorgys I started my Letrozole today, I decided to take mine in the morning along with my calcium tablet, and see how I go. No noticeable side effects today, but I suppose time will tell. I'm taking mine with food, I don't like taking medication on an empty stomach unless I have to. I also had my first Goserelin injection last week as I'm pre menopausal, and no noticeable side effects so far. I was already getting hot flushes and they don't seem any worse. I'm keeping up my exercise, and back doing aqua aerobics again.