Hi - I had my Chemo first then my masectomy, I start radiation today. Unlike you I had triple negative BC, which means that Chemo is your only option. I was also Stage 3 with very agressive tumors, I had 10 in all ranging from 2cm to 5cm. The best news I got was that I had a complete pathological response to the chemo so when they did surgery their was only dead cancer cells found.I know how you feel wanting the cancer gone, but you need to rely on what your specialists are telling you. I had 16 rounds of chemo over 4.5 months - it was brutal but definately doable. It is the end result that you are aiming for, how you go about it is not as important. Good luck Sue