Can cancer return after you've had a unilateral mastectomy; chemo; Herception, inhibitor?

Here we go again had left bc lumpectomy this time last year followed by 6 months chemo 6 weeks radiotherapy and on hormone therapy. Had follow up with surgeon yesterday along with a mammogram which showed right breast calcifications cysts, now awaiting vacuum biopsy on Friday. Just when you think things are getting back on track your hit in the face again