Hi @salpal, in general, life on the trial is quite okay. I'm on cycle 9 of 24 of the trial. There are no major side effects that I can directly attribute to palbociclib. There's definitely fatigue, which means there's really nothing left in the energy bank for any kind of paid work after taking care of my kids. Luckily I have income insurance through my super keeping me afloat for now. I suffer from persistent sciatica, but this is more likely from carrying the extra kgs I gained from chemo and haven't lost. I was loosing weight on tamoxifen/palbociclib combo but I've been changed to zoladex plus aromisin with the palbo and back on the weight gain train... sigh! Otherwise, my neutrophils drop significantly each cycle, but not enough to stall the next cycle and I've not been sick becsuse of it. I often wonder if my recovery from chemo/radio would be greater if I weren't on the trial, but my tumor spanned 9cm with vascular involvement, so I'm happy for the extra line of preventative treatment despite the side effects. I'll be 42 when I finish the trial, and my kids are very little.
