Oncotype DX

Hi. I was diagnosed with an unusual mucinous BC late October 2019. Two surgeries, the second re-excision and SLNB early November. It's now December. Initially told it's Stage 2A (T2 N0 M0) but now my case will be reviewed because the oncologist thinks the tumour in the axilla might actually be a lymph node and not breast tissue. Still no clear treatment plan. Haven't slept properly for weeks. I've just paid $5000 for the Oncotype DX Breast Test. Hope it's worth it. Another two weeks wait for that and for the MDT to meet again.
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It sounds like your Oncologist is being very careful which is great. You want to be going the right way when you set off, and hopefully the Oncotype will give you more information.
I understand the sleeplessness, it is so common round here. I have been using audiobooks from the library on my phone when I wake in the night to distract my busy mind.
Sending you white light and good luck!
Therefore, I conclude that the expense ($5000) of the Oncotype DX genomic assay is well worth it.
My medical oncologists said they advocate for the test to be covered by the Pharmaceutical Benefits Scheme (PBS). They want patients/the public to advocate for Oncotype DX too. How do we go about that? I was able to afford it (just), but I would like everyone who is a suitable candidate to be able to access the test. In the long term, it would spare many people from having chemo unnecessarily - and spare the public health system the expense of chemo and the cost of dealing with subsequent health issues.
Who Might Benefit from the Oncotype DX Breast Cancer Assay?
The Oncotype DX breast cancer assay can be used by all patients newly diagnosed with early stage, invasive breast cancer who are:
Shame an Aussie company doesn't start off the same test here
"The Oncotype DX test has been available in Canada since the end of 2007, and to date, over 30,000 Canadian women have benefited from testing. There is publicly funded coverage for the Oncotype DX Breast Cancer Assay patients in a number of Canadian provinces including British Columbia, Alberta, Saskatchewan Manitoba, Ontario, Quebec, Nova Scotia, PEI and Newfoundland. Individual patients also have the option of paying for the test themselves if there is no coverage in their province, or if they do not meet pre-specified provincial eligibility criteria." https://www.oncotypeiq.com/en-CA/breast-cancer/patients-and-caregivers/stage-i-iiia-invasive/eligibility-and-testing
See the online event and pertinent article.
I have submitted a question about fear of recurrence and the reliability of the $5000.00 Oncotype DX genomic assay to -
Breast Cancer Trials Q&A Event from 6-7pm, 7 October 2020 (AEDT).
To watch the Q&A, please click on the following link and enter your details:
https://webcast.gigtv.com.au/Mediasite/Play/38c05001e60a46b1b01ecb7d25b8727c1d
Should you require tech support, please contact: https://www.gigtv.com.au/support/
The following article perhaps sheds some light on why the MSAC did not approve a Medicare rebate for the test. On the one hand, it is not surprising that Oncotype company keeps their total methodology to themselves - but, their opacity resists all efforts to prove their hypothesis.
Oncotype DX Breast Cancer recurrence score resists inter-assay reproducibility with RT2-Profiler Multiplex RT-PCR
https://www.nature.com/articles/s41598-019-56910-0
"In the Cancer Biology Reproducibility Study the Errington group justifiably demands that retesting a hypothesis with the same or a closely related methodology should provide the same evidence that in turn enables the investigator to converge on an explanation for the finding that is not dependent on either methodology3. This inter-assay reproducibility was obviously not fulfilled for the Oncotype DX in comparison to the RT2-Profiler assay, which is due to the fact that the Oncotype DX assay remains a black box. Several parameters are not reported at all, while other parameters are reported in a way that differs from all claims in the original publication and the patent files available for the assay (International Patent Publication Numbers WO2006/052862A1 and WO2014/130617A1), as shown in the results."