This is an interesting thread. I am in my 70s and had ER+ PR- HER2+ cancer. Chemo and rads plus herceptin (last infusion a couple of weeks ago - exciting after 15 months of various infusions 😊) and started letrozole in April. Due to complete hysterectomy at 43 had osteopenia before all this started and had a base line bone density test done before starting chemo. Just had another one and now have osteoporosis in spine and osteopenia in hips though they showed marked decline. I expected to be given something stronger than caltrate and vit d which I have been taking for years but onc said the same about prolia as your GP @JulieVT11 and he doesn’t like the side effects of the others (made me smile coming from an onc). He said that tamoxifen is good for bone density and will stop the decline and even improve it. I am a bit concerned about following this path and intend to discuss it with my GP but am wondering if anyone else has tried this path and what happened to their bone density. The last thing I need atm or ever is a serious fracture. I am also a bit concerned about the efficacy of tamoxifen compared to letrozole in preventing recurrence as tumour cells were 95% ER+. Would be very interested in any info you ladies may have on either issue.