Letrozole Joint Pain & Exercise
I've been on Letrozole since August 2018 and have had a lot of joint pain and for the last few weeks, soft tissue issues with my knee as well (area of an old ligament injury). I'm cautious about sayi...
Forum Discussion
Prednisone in small 5mg daily doses for a week helped this in study. They say it also helped prevent people from going off AIs .... but didn’t suggest the follow up regime .... whether one week a month (that I could see.)
i was on a bigger dose for 1 week before the big uke festival that I was playing in .... and the extended relief it gave was terrific. Hmmmm could be worth a go now and then, not full time tho? Check with your GP. The low dose occasionally isn’t as bad as the high doses re affecting bone density and fractures, apparently
http://ar.iiarjournals.org/content/32/6/2331.full
QUOTE. Low-dose (5 mg) of oral prednisolone administration once a day in the morning for only seven days is a safe method that does not require steroid coverage .......//......... The mechanism of the efficacy of prednisolone in AI-induced arthralgia is unclear; however, our aim is to reduce cases of AI-induced arthralgia that are severe enough to force patients off of AI therapy. Clearly, patient education is the first step towards managing AI-induced arthralgia successfully, as it is important that patients comprehend the significance of total adherence to AI regimens. The findings of this study are limited by its small sample size and by the lack of a concurrent control group. However, despite these limitations, our results suggest that low-dose/short term prednisolone is a substitute for NSAIDs, acetoaminophen and COX-2 inhibitors for patients who suffer from AI-induced arthralgia, and may prevent patients from dropping out of AI treatment. UNQUOTE
i was on a bigger dose for 1 week before the big uke festival that I was playing in .... and the extended relief it gave was terrific. Hmmmm could be worth a go now and then, not full time tho? Check with your GP. The low dose occasionally isn’t as bad as the high doses re affecting bone density and fractures, apparently
http://ar.iiarjournals.org/content/32/6/2331.full
QUOTE. Low-dose (5 mg) of oral prednisolone administration once a day in the morning for only seven days is a safe method that does not require steroid coverage .......//......... The mechanism of the efficacy of prednisolone in AI-induced arthralgia is unclear; however, our aim is to reduce cases of AI-induced arthralgia that are severe enough to force patients off of AI therapy. Clearly, patient education is the first step towards managing AI-induced arthralgia successfully, as it is important that patients comprehend the significance of total adherence to AI regimens. The findings of this study are limited by its small sample size and by the lack of a concurrent control group. However, despite these limitations, our results suggest that low-dose/short term prednisolone is a substitute for NSAIDs, acetoaminophen and COX-2 inhibitors for patients who suffer from AI-induced arthralgia, and may prevent patients from dropping out of AI treatment. UNQUOTE