2 years on Prolia injections have significant affect on Bone Density improvement.

Am not sure why your back might go if you start the injection ?

I probably need a root canal tooth dealt with before I start Prolia. I wonder f my back will go if I start with the injection.

ie BEFORE embarking on either Bisphosphonates or Prolia ensure you have a thorough dental examination and all major dental work done. 

It is my understanding there is less risk of ONJ with Prolia as it fully exits the system after 6 months unlike Bisphosphonates.For this reason I have a small break between the ending of one injection and having another injection to have dental work done.I also had 8 dental implants 6/17 prior to starting Prolia 8/17 .

@Romla yes my Oncologist also said from the onset that Prolia adds extra protection against BC, they didn't quite understand but it does. Yes one complication can be as you said Osteonecrosis of the Jaw(ONJ)....Osteonecrosis of the jaw is another side effect of Prolia, but it's extremely rare (about one in a thousand). After a 10-year study, six of 4,550 participants developed the disease, according to results published in 2013.

I didnt have osteoporosis prior to chemo, I did suffer backache post though, my backache also has gone and made sense with the spine results. :) 

I have found the added benefit of Prolia far outweighs all else in my 2yr experience with zero side effects, I'd recommend anyone who is recommended this by their Oncologist...it works with added benefits. :)

PS I can’t comment on bone density improvement as have yet to have my bone density checked since starting Prolia. I can however report my Osteoporosis was picked up from backache I had sitting at length on the bus coming home from work.I have no lower back pain now but have sore ribs where the fracture occurred and radiotherapy was administered.

I have been on Prolia since 8/17 and am also on the Aromatase Inhibitor Letrozole/ Femara. At the outset I had already been diagnosed with osteoporosis and had had an osteoporotic fracture - Prolia is thus a lifetime treatment for me. 

I was very very worried about this treatment as had read a lot on linethat was not encouraging. I spoke to a lot of friends and my longtime GP all of whom said my fears were baseless in their experience and in my case I have found it to be true.

One positive I have read is that Prolia in conjunction with an AI has been found to further reduce recurrence risk as they are synergistic.This research was delivered at the 2016 Breast Cancer Interntaional Congress in Austin Texas and can be read about online. I have read In NYC it is given to breast cancer patients who are not osteoporotic for this reason alone.

Prolia does exit the system quickly after 6 months but that allows a small window wherein I have dental treatment which is very difficult with bisphosphonate tablets.I have had bisphosphonate tablets twice some years ago for roughly 3 months each time. the first time I developed an ulcer as you must be upright for a minimum of 30 minutes after taking the tablet - sitting up in bed is inadequate . I ceased the tablets and recommenced the following year for about 3months. I needed an extraction and found it very difficult to find a dentist or dental specialist who would help me once they learned I had taken Bisphosphonates.Bisphonates can cause Osteonecrosis of the Jaw(ONJ) with major dental like root canals , extrcati9ns etc. Bisphosphonates unlike Prolia stay in the system indefinitely ie Prolia exits your system entirely after 6 months but Bisphosphonates stay in your body even after you cease taking them so the risk of ONJ is indefinite.I was lucky to meet Professor Goss of our dental school who agreed to help me but only after a crosslaps test established my bone was still turning over - I believe if I had been on Bisphosphonates for a lengthier period that would not have been the case.

I ceased Bisphosphonates after this episode .I continued on with Caltrate based on the Osteoporosis Australia clinical guidelines at the time for my circumstances. I discovered only recently they changed Nov 2017 and in particular they are now concerned about calcium and it’s impact on the heart. The document I mention is on line and lengthy but has a table of contents to enable quick selection of topics - there is a section for those who have had breast cancer too - I highly recommend a read.

Hope this helps and happy to answer questions within my experience.

Thanks @Nikkid the Oncologist was really happy over it. I thought it may have been of interest as Prolia has been a topic in various threads @Romla and @Chris. 

@Primek absolutely, as I said Prolia is NOT the only reason for the improvement. I worked with an Exercise Physiologist and am very active. 

Prolia (Denosumab)

A twice-a-year injection, denosumab is a monoclonal antibody — a biologic drug. It turns off the stimulus for the type of cells that break down bone, osteoclasts, which decreases bone loss and prevents broken bones.

Pros: It’s highly effective in treating osteoporosis. According to the National Osteoporosis Foundation (NOF), the drug helped lower new spine fractures by 68 percent and hip fractures by 40 percent. Non-spine fracture incidence fell 20 percent over three years.

Cons: Denosumab could cause your calcium level to go down, so it’s important to get your level checked through a blood test. If you have a low calcium level, called hypocalcemia, you would not take this drug.

There are pros and cons for all treatment, depending on an individual situation as to what suits best, I was really happy with the improvement and wanted to share..

You go @melclarity - great news!!!! xxxx

I suppose the oncologist focus is only on your health whilst under treatment. As we all plan to live a full, long life looking beyond that time is important.